Mosteller formula (the modern standard for adult clinical use): BSA = √(weight × height / 3600). Simple, accurate, easy to compute mentally. DuBois formula (1916, historic reference): BSA = 0.007184 × W^0.425 × H^0.725. Calibrated against direct surface area measurements of nine subjects (small sample, hence its limitations at extremes). Haycock formula (1978, pediatric preferred): BSA = 0.024265 × W^0.5378 × H^0.3964. Validated on a larger pediatric population.
Clinical applications of BSA: Chemotherapy dosing (most agents specified in mg/m²), pediatric drug dosing (where adult dosing rules don't apply), cardiac index (cardiac output normalised to BSA, used in heart-failure assessment), burn severity (% Total Body Surface Area burned guides fluid resuscitation), renal clearance normalization (eGFR per 1.73m²), and intravenous fluid calculations.
Limitations: BSA overestimates surface area in extreme obesity (BMI 40+) and can lead to chemotherapy toxicity if used naively. Many oncology protocols cap BSA at 2.0 m² for dose calculation to limit drug exposure. For pediatric calculations, Haycock or Mosteller should be used; older formulas (Boyd's table) are less accurate. Even with the right formula, BSA estimates are within ±5% of measured surface area - sufficient for clinical dosing but not exact.